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Разо таб. п/о кш/раств., 10 мг, 15 шт.

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4.6
(20)
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Коротко о товаре

Артикул Маркета
4111758819
Тип препарата
Назначение
Действующее вещество
Возраст
от 12 лет
Инструкция
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Оболочка: зеин 2,45 мг, триэтилцитрат 0,25 мг, Оболочка кишечнорастворимая: метакриловой кислоты и этилакрилата сополимер [1:1](метакриловой кислоты сополимер (тип С)) 12,05 мг, триэтилцитрат 1,20 мг, тальк 0,65 мг. Оболочка: Опадрай розовый О3В54475 2,70 мг (гипромеллоза 6сР 62,50%, титана диоксид (Е171) 28,70%, макрогол-400 6,25%, краситель железа оксид красный (Е172) 2,55%)."},{"name":"Действующее вещество","value":"Рабепразол","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["27144131:28709641"]}}},{"name":"Способ применения и дозы","value":"Таблетки принимают внутрь целиком, не разжевывая и не измельчая. Установлено, что ни время суток, ни прием пищи не влияют на активность рабепразола.\u003Cbr\u003E\nПри язвенной болезни желудка в стадии обострения и язве анастомоза рекомендуется принимать внутрь по 10 мг или по 20 мг один раз в день. Обычно излечение наступает после 6 недель терапии, однако в некоторых случаях длительность лечения может быть увеличена еще на 6 недель. \u003Cbr\u003E\nПри язвенной болезни двенадцатиперстной кишки в стадии обострения рекомендуется принимать внутрь по 20 мг один раз в день. В некоторых случаях лечебный эффект наступает при приеме 10 мг один раз в день. Длительность лечения составляет от 2 до 4 недель. В случае необходимости длительность лечения может быть увеличена еще на 4 недели. \u003Cbr\u003E\nПри лечении эрозивной гастроэзофагеальной рефлюксной болезни или рефлюкс-эзофагите рекомендуется принимать внутрь по 10 мг или по 20 мг один раз в день. Длительность лечения составляет от 4 до 8 недель. В случае необходимости длительность лечения может быть увеличена еще на 8 недель. \u003Cbr\u003E\nПри поддерживающей терапии гастроэзофагеальной рефлюксной болезни рекомендуется принимать внутрь по 10 мг или по 20 мг один раз в день. Длительность лечения зависит от состояния пациента. \u003Cbr\u003E\nПри неэрозивной гастроэзофагеальной рефлюксной болезни рекомендуется принимать внутрь по 10 мг или по 20 мг один раз в день. Если после четырех недель лечения симптомы не исчезают, следует провести дополнительное исследование пациента. После купирования симптомов для предупреждения их последующего возникновения следует принимать препарат внутрь в дозе 10 мг один раз в день. \u003Cbr\u003E\nДля лечения синдрома Золлингера-Эллисона и других состояний, характеризующихся патологической гиперсекрецией дозу подбирают индивидуально. Начальная доза - 60 мг в день, затем дозу повышают и назначают препарат в дозе до 100 мг в день при однократном приеме или по 60 мг два раза в день. Для некоторых пациентов дробное дозирование препарата является предпочтительным. Лечение должно продолжаться по мере клинической необходимости. У некоторых больных с синдромом Золлингера-Эллисона длительность лечения рабепразолом может составлять до одного года. \u003Cbr\u003E\nДля эрадикации Helicobacter pylori рекомендуется принимать внутрь по 20 мг два раза в день по определенной схеме с соответствующей комбинацией антибиотиков. Длительность лечения составляет 7 дней. \u003Cbr\u003E\nПациенты с почечной и печеночной недостаточностью. Коррекция дозы пациентам с почечной недостаточностью не требуется. У пациентов с легкой и умеренной степенью печеночной недостаточности концентрация рабепразола в крови обычно выше, чем у здоровых пациентов. При назначении препарата Разо пациентам с тяжелой степенью печеночной недостаточности следует соблюдать осторожность. \u003Cbr\u003E\nДети. Безопасность и эффективность применения рабепразола у детей в возрасте 12 лет и старше установлена для краткосрочного (до 8 недель) лечения ГЭРБ. Рекомендуемая доза для детей в возрасте 12 лет и старше составляет 20 мг 1 раз в день продолжительностью до 8 недель. Безопасность и эффективность рабепразола для применения по другим показаниям не установлена для пациентов детского возраста."},{"name":"Побочные действия","value":"Нарушения со стороны нервной системы: нечасто - головная боль, головокружение. \u003Cbr\u003E\nНарушения со стороны желудочно-кишечного тракта: часто - запор, диарея, боль в животе, сухость слизистой оболочки полости рта, метеоризм; редко - гепатит, желтуха; у пациентов с циррозом печени - печеночная энцефалопатия. \u003Cbr\u003E\nНарушения со стороны кожи и подкожных тканей: редко - крапивница, буллезные высыпания, синдром Лайелла (токсический эпидермальный некролиз), синдром Стивенса-Джонсона (тяжелая многоформная эритема, характеризующаяся появлением пятен и пузырей на коже и слизистых оболочках на фоне высокой температуры и боли в суставах). \u003Cbr\u003E\nНарушения со стороны скелетно-мышечной и соединительной ткани: редко - миалгия, артралгия. \u003Cbr\u003E\nНарушения со стороны почек и мочевыводящих путей: очень редко - интерстициальный нефрит. \u003Cbr\u003E\nЛабораторные и инструментальные данные: редко - тромбоцитопения, нейтропения, лейкопения, лейкоцитоз, повышение активности \"печеночных\" ферментов (трансаминаз), гипомагниемия. Возможно увеличение риска возникновения переломов костей"},{"name":"Фармакологическое действие","value":"Механизм действия. Рабепразол относится к классу антисекреторных соединений, которые в химическом отношении являются замещенными бензимидазолами. Препарат угнетает активность фермента H+/К+АТФ-азы (\"протонный насос\"), блокируя тем самым заключительную стадию синтеза соляной кислоты. Этот эффект носит дозозависимый характер и приводит к угнетению как базальной, так и стимулированной секреции соляной кислоты независимо от раздражителя. Как слабое основание рабепразол в любых дозах быстро абсорбируется и концентрируется в кислой среде париетальных клеток. Антисекреторная активность. После приема внутрь 20 мг рабепразола антисекреторный эффект возникает в течение одного часа. Угнетение базальной и стимулированной секреции соляной кислоты через 23 часа после приема первой дозы рабепразола натрия составляет 62 и 82%, соответственно, и продолжается до 48 часов. Такая продолжительность фармакокинетического действия намного превышает предсказуемое по периоду полувыведения (примерно на 1 час). Данный эффект может быть объяснен продолжительным связыванием лекарственного вещества с Н+/К+АТФ-азой париетальных клеток желудка. Величина ингибирующего действия рабепразола натрия на секрецию кислоты достигает плато после трех дней приема рабепразола натрия. При прекращении приема секреторная активность восстанавливается в течение 142 дней. Влияние на концентрацию гастрина в сыворотке. В начале терапии рабепразолом концентрация гастрина в сыворотке крови увеличивается, что является отражением ингибирующего влияния на секрецию соляной кислоты. Концентрация гастрина возвращается к исходному уровню обычно в течение 1~2 недель после прекращения лечения.\u003Cbr\u003E\nВлияние на энтерохромафинноподобные клетки. Изучение биоптатов дна и антрального отдела желудка более чем у 500 пациентов, получавших рабепразол натрия или препарат сравнения продолжительностью до 8 недель, не выявило изменений в морфологической структуре энтерохромафинноподобных (ЕСL) клеток, степени выраженности гастрита,частоте атрофического гастрита, кишечной метаплазии или распространенности инфекции Неlicоbactet pуlоri. В исследовании с участием более 400 пациентов, получавших рабепразол в дозе 10 мг/день или 20 мг/день, продолжительностью до 1 года, частота гиперплазии была низкой и сравнимой с таковой для пациентов, получавших омепразол в дозе 20 мг/день. Не был зарегистрирован ни один случай аденоматозных изменений или карциноидных опухолей, наблюдавшихся у крыс. \u003Cbr\u003E\nДругие эффекты.В настоящее время нет данных о том, что рабепразол вызывает системные эффекты со стороны центральной нервной системы (ЦНС), сердечно-сосудистой и дыхательной систем. При пероральном приеме в дозе 20 мг в течение 2 недель рабепразол не оказывал влияния на функцию щитовидной железы, метаболизм углеводов, а также на концентрации в крови паратиреоидного гормона, кортизола, эстрогенов, тестостерона, пролактина, секретина,глюкагона, фолликулостимулирующего гормона, лютеинизирующего гормона, ренина, альдостерона и соматотропного гормона."},{"name":"Фармакологическая группа","value":"ингибиторы протонного насоса"},{"name":"Форма выпуска","value":"таблетки"},{"name":"Способ применения/введения","value":"пероральный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["35947170:36763744"]}}},{"name":"Минимальный возраст применения","value":"от 12 лет"},{"name":"Условия хранения","value":"При температуре не выше 25 °С. Хранить в недоступном для детей месте."},{"name":"Передозировка","value":"Симптомы. Данные о намеренной или случайной передозировке минимальны. Сообщалось о приеме препарата в дозе 60 мг 2 раза в день или 160 мг однократно, при этом побочные эффекты были минимальны и обратимы и не требовали медицинского вмешательства. Лечение. Специфический антидот для препарата Разо неизвестен. Рабепразол хорошо связывается с белками плазмы, поэтому слабо выводится при диализе. При передозировке необходимо проводить симптоматическое и поддерживающее лечение."},{"name":"Применение при беременности и кормлении грудью","value":"Данных по безопасности применения рабепразола во время беременности нет. Исследования репродуктивности на крысах и кроликах не выявили признаков нарушения фертильности или дефектов развития плода, обусловленных рабепразолом; однако у крыс в небольших количествах препарат проникает через плацентарный барьер. Рабепразол не следует применять при беременности. Неизвестно, выделяется ли рабепразол с грудным молоком. Соответствующие исследования у кормящих женщин не проводились. Вместе с тем рабепразол обнаружен в молоке лактирующих крыс, поэтому препарат нельзя применять в период грудного вскармливания."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Исходя из особенностей фармакодинамики рабепразола и его профиля нежелательных эффектов, маловероятно, что препарат Разо оказывает влияние на способность управлять транспортными средствами и выполнять другие виды деятельности, требующие концентрации внимания и быстроты психомоторных реакций. Однако в случае появления сонливости, головокружения следует избегать этих видов деятельности."},{"name":"Особые указания","value":"Ответ пациента на терапию рабепразолом натрия не исключает наличие злокачественных новообразований в желудке.\u003Cbr\u003E\nДо и после лечения обязателен эндоскопический контроль для исключения злокачественного новообразования, так как лечение может замаскировать симптоматику и отстрочить правильную диагностику. \u003Cbr\u003E\nРекомендуется соблюдать осторожность при первом назначении препарата Разо пациентам с тяжелыми нарушениями функции печени. \u003Cbr\u003E\nПациентам с нарушениями функции почек или печени корректировка дозы препарата Разо не требуется. AUC рабепразола натрия у пациентов с тяжелым нарушением функции печени примерно в два раза выше, чем у здоровых пациентов. \u003Cbr\u003E\nПрепарат не оказывает влияния на функцию щитовидной железы, метаболизм углеводов, на концентрацию в крови паратиреоидного гормона, кортизола, эстрогена, тестостерона, пролактина, холецистокинина, секретина, глюкагона, фолликулостимулирующего гормона, лютеинизирующего гормона, ренина, альдостерона и соматотропного гормона. \u003Cbr\u003E\nСогласно данным наблюдательных исследований терапия ингибиторами протонной помпы может привести к возрастанию риска связанных с остеопорозом переломов бедра, запястья, позвоночника. Риск переломов был увеличен у пациентов, получавших высокие дозы ингибиторов протонной помпы год и более."},{"name":"Взаимодействие","value":"В исследованиях in vitro на микросомах печени человека было показано, что рабепразолметаболизируется в печени изоферментами CYP2C19 и CYP3A4.\u003Cbr\u003E\nРабепразол не вступает в клинически значимые взаимодействия с амоксициллином и с другими лекарственными средствами, метаболизируемыми изоферментами системы цитохрома Р450 в печени: варфарином, фенитоином, теофиллином и диазепамом. \u003Cbr\u003E\nВ связи с тем, что рабепразол вызывает выраженное и длительное снижение выработки соляной кислоты, отмечалось взаимодействие при одновременном приеме с препаратами, абсорбция которых зависит от кислотности содержимого желудка. У здоровых добровольцев прием рабепразола вызывал снижение концентрации кетоконазола в плазме крови на 30% и повышение минимальной концентрации дигоксина на 22%. При одновременном приеме рабепразола с кетоконазолом или дигоксином необходимо корректировать их дозы. \u003Cbr\u003E\nПри одновременном приеме атазанавира 300 мг / ритонавира 100 мг с омепразолом (40 мг 1 раз в день) или с атазанавира 400 мг с лансопразолом (60 мг 1 раз в день) здоровыми добровольцами наблюдалось существенное снижение воздействия атазанавира. Абсорбция атазанавира зависит от pH. Таким образом, не рекомендуется одновременный прием атазанавира с ингибиторами протонного насоса, включая рабепразол. \u003Cbr\u003E\nКонцентрации рабепразола и активного метаболита кларитромицина в плазме крови при одновременном приеме увеличиваются на 24% и 50%, соответственно. Данный эффект используется при проведении эрадикации Helicobacter pylori. \u003Cbr\u003E\nОдновременный прием рабепразола и метотрексата может привести к повышению концентрации метотрексата и его метаболита гидроксиметотрексата и увеличить время их выведения. \u003Cbr\u003E\nНе обнаружено взаимодействия рабепразола с жидкими антацидными препаратами. \u003Cbr\u003E\nНе выявлено клинически значимого взаимодействия рабепразола с пищей."},{"name":"Регистрационный номер","value":"ЛП-002666"},{"name":"Дата государственной регистрации","value":"30.05.2018"},{"name":"Владелец регистрационного удостоверения","value":"Dr. Reddy's Laboratories","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["34324371:35649313","7893318:16077120"]}}},{"name":"Изготовитель","value":"Dr. Reddy's"},{"name":"Фасовщик","value":"Dr. Reddy's"},{"name":"Страна бренда","value":"Индия"},{"name":"Страна-производитель","value":"Индия"},{"name":"Название препарата","value":"Разо","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-pishchevareniia","categoryId":"15756506","navnodeId":"72470","glfilters":["17796364:18008653"]}}},{"name":"Срок годности","value":"35 мес."}]}},"fullSpecsGrouped":{"7169844028213231039":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Органы и системы","value":"желудок, пищеварительная система"},{"name":"Назначение","value":"гастроэзофагиальный рефлюкс, язвенная болезнь желудка и двенадцатиперстной кишки"},{"name":"Показания к применению","value":"- язвенная болезнь желудка в стадии обострения и язва анастомоза;\u003Cbr\u003E\n- язвенная болезнь двенадцатиперстной кишки в стадии обострения;\u003Cbr\u003E\n- эрозивная и язвенная гастроэзофагеальная рефлтоксная болезнь или рефлюкс-эзофагит;\u003Cbr\u003E\n- поддерживающая терапия гастроэзофагеальной рефлюксной болезни;\u003Cbr\u003E\n- неэрозивная гастроэзофагеальная рефлюксная болезнь;\u003Cbr\u003E\n- синдром Золлингера-Эллисона и другие состояния, характеризующиеся патологической гиперсекрецией.\u003Cbr\u003E\nВ составе комбинированной терапии:\u003Cbr\u003E\n- эрадикация Helicobacter pylori у пациентов с язвенной болезнью желудка и двенадцатиперстной кишки или хроническим гастритом."},{"name":"Противопоказания","value":"Повышенная чувствительность к рабепразолу, замещенным бензимидазолам или к вспомогательным компонентам препарата; беременность; период грудного вскармливания (лактации); детский возраст до 12 лет."},{"name":"Состав","value":"Каждая таблетка, покрытая кишечнорастворимой оболочкой, 10 мг содержит: действующее вещество: рабепразол натрия 10 мг; вспомогательные вещества: маннитол 48,505 мг, гипролоза низкозамещенная 7,20 мг,магния оксид тяжелый 20,00 мг, гипромеллоза (5срs) 1,50 мг, натрия лаурилсульфат 0,90мг,тальк 0,77 мг, магния стеарат 1,125 мг. Оболочка: зеин 2,45 мг, триэтилцитрат 0,25 мг, Оболочка кишечнорастворимая: метакриловой кислоты и этилакрилата сополимер [1:1](метакриловой кислоты сополимер (тип С)) 12,05 мг, триэтилцитрат 1,20 мг, тальк 0,65 мг. Оболочка: Опадрай розовый О3В54475 2,70 мг (гипромеллоза 6сР 62,50%, титана диоксид (Е171) 28,70%, макрогол-400 6,25%, краситель железа оксид красный (Е172) 2,55%)."},{"name":"Действующее вещество","value":"Рабепразол"},{"name":"Способ применения и дозы","value":"Таблетки принимают внутрь целиком, не разжевывая и не измельчая. Установлено, что ни время суток, ни прием пищи не влияют на активность рабепразола.\u003Cbr\u003E\nПри язвенной болезни желудка в стадии обострения и язве анастомоза рекомендуется принимать внутрь по 10 мг или по 20 мг один раз в день. Обычно излечение наступает после 6 недель терапии, однако в некоторых случаях длительность лечения может быть увеличена еще на 6 недель. \u003Cbr\u003E\nПри язвенной болезни двенадцатиперстной кишки в стадии обострения рекомендуется принимать внутрь по 20 мг один раз в день. В некоторых случаях лечебный эффект наступает при приеме 10 мг один раз в день. Длительность лечения составляет от 2 до 4 недель. В случае необходимости длительность лечения может быть увеличена еще на 4 недели. \u003Cbr\u003E\nПри лечении эрозивной гастроэзофагеальной рефлюксной болезни или рефлюкс-эзофагите рекомендуется принимать внутрь по 10 мг или по 20 мг один раз в день. Длительность лечения составляет от 4 до 8 недель. В случае необходимости длительность лечения может быть увеличена еще на 8 недель. \u003Cbr\u003E\nПри поддерживающей терапии гастроэзофагеальной рефлюксной болезни рекомендуется принимать внутрь по 10 мг или по 20 мг один раз в день. Длительность лечения зависит от состояния пациента. \u003Cbr\u003E\nПри неэрозивной гастроэзофагеальной рефлюксной болезни рекомендуется принимать внутрь по 10 мг или по 20 мг один раз в день. Если после четырех недель лечения симптомы не исчезают, следует провести дополнительное исследование пациента. После купирования симптомов для предупреждения их последующего возникновения следует принимать препарат внутрь в дозе 10 мг один раз в день. \u003Cbr\u003E\nДля лечения синдрома Золлингера-Эллисона и других состояний, характеризующихся патологической гиперсекрецией дозу подбирают индивидуально. Начальная доза - 60 мг в день, затем дозу повышают и назначают препарат в дозе до 100 мг в день при однократном приеме или по 60 мг два раза в день. Для некоторых пациентов дробное дозирование препарата является предпочтительным. Лечение должно продолжаться по мере клинической необходимости. У некоторых больных с синдромом Золлингера-Эллисона длительность лечения рабепразолом может составлять до одного года. \u003Cbr\u003E\nДля эрадикации Helicobacter pylori рекомендуется принимать внутрь по 20 мг два раза в день по определенной схеме с соответствующей комбинацией антибиотиков. Длительность лечения составляет 7 дней. \u003Cbr\u003E\nПациенты с почечной и печеночной недостаточностью. Коррекция дозы пациентам с почечной недостаточностью не требуется. У пациентов с легкой и умеренной степенью печеночной недостаточности концентрация рабепразола в крови обычно выше, чем у здоровых пациентов. При назначении препарата Разо пациентам с тяжелой степенью печеночной недостаточности следует соблюдать осторожность. \u003Cbr\u003E\nДети. Безопасность и эффективность применения рабепразола у детей в возрасте 12 лет и старше установлена для краткосрочного (до 8 недель) лечения ГЭРБ. Рекомендуемая доза для детей в возрасте 12 лет и старше составляет 20 мг 1 раз в день продолжительностью до 8 недель. Безопасность и эффективность рабепразола для применения по другим показаниям не установлена для пациентов детского возраста."},{"name":"Побочные действия","value":"Нарушения со стороны нервной системы: нечасто - головная боль, головокружение. \u003Cbr\u003E\nНарушения со стороны желудочно-кишечного тракта: часто - запор, диарея, боль в животе, сухость слизистой оболочки полости рта, метеоризм; редко - гепатит, желтуха; у пациентов с циррозом печени - печеночная энцефалопатия. \u003Cbr\u003E\nНарушения со стороны кожи и подкожных тканей: редко - крапивница, буллезные высыпания, синдром Лайелла (токсический эпидермальный некролиз), синдром Стивенса-Джонсона (тяжелая многоформная эритема, характеризующаяся появлением пятен и пузырей на коже и слизистых оболочках на фоне высокой температуры и боли в суставах). \u003Cbr\u003E\nНарушения со стороны скелетно-мышечной и соединительной ткани: редко - миалгия, артралгия. \u003Cbr\u003E\nНарушения со стороны почек и мочевыводящих путей: очень редко - интерстициальный нефрит. \u003Cbr\u003E\nЛабораторные и инструментальные данные: редко - тромбоцитопения, нейтропения, лейкопения, лейкоцитоз, повышение активности \"печеночных\" ферментов (трансаминаз), гипомагниемия. Возможно увеличение риска возникновения переломов костей"},{"name":"Фармакологическое действие","value":"Механизм действия. Рабепразол относится к классу антисекреторных соединений, которые в химическом отношении являются замещенными бензимидазолами. Препарат угнетает активность фермента H+/К+АТФ-азы (\"протонный насос\"), блокируя тем самым заключительную стадию синтеза соляной кислоты. Этот эффект носит дозозависимый характер и приводит к угнетению как базальной, так и стимулированной секреции соляной кислоты независимо от раздражителя. Как слабое основание рабепразол в любых дозах быстро абсорбируется и концентрируется в кислой среде париетальных клеток. Антисекреторная активность. После приема внутрь 20 мг рабепразола антисекреторный эффект возникает в течение одного часа. Угнетение базальной и стимулированной секреции соляной кислоты через 23 часа после приема первой дозы рабепразола натрия составляет 62 и 82%, соответственно, и продолжается до 48 часов. Такая продолжительность фармакокинетического действия намного превышает предсказуемое по периоду полувыведения (примерно на 1 час). Данный эффект может быть объяснен продолжительным связыванием лекарственного вещества с Н+/К+АТФ-азой париетальных клеток желудка. Величина ингибирующего действия рабепразола натрия на секрецию кислоты достигает плато после трех дней приема рабепразола натрия. При прекращении приема секреторная активность восстанавливается в течение 142 дней. Влияние на концентрацию гастрина в сыворотке. В начале терапии рабепразолом концентрация гастрина в сыворотке крови увеличивается, что является отражением ингибирующего влияния на секрецию соляной кислоты. Концентрация гастрина возвращается к исходному уровню обычно в течение 1~2 недель после прекращения лечения.\u003Cbr\u003E\nВлияние на энтерохромафинноподобные клетки. Изучение биоптатов дна и антрального отдела желудка более чем у 500 пациентов, получавших рабепразол натрия или препарат сравнения продолжительностью до 8 недель, не выявило изменений в морфологической структуре энтерохромафинноподобных (ЕСL) клеток, степени выраженности гастрита,частоте атрофического гастрита, кишечной метаплазии или распространенности инфекции Неlicоbactet pуlоri. В исследовании с участием более 400 пациентов, получавших рабепразол в дозе 10 мг/день или 20 мг/день, продолжительностью до 1 года, частота гиперплазии была низкой и сравнимой с таковой для пациентов, получавших омепразол в дозе 20 мг/день. Не был зарегистрирован ни один случай аденоматозных изменений или карциноидных опухолей, наблюдавшихся у крыс. \u003Cbr\u003E\nДругие эффекты.В настоящее время нет данных о том, что рабепразол вызывает системные эффекты со стороны центральной нервной системы (ЦНС), сердечно-сосудистой и дыхательной систем. При пероральном приеме в дозе 20 мг в течение 2 недель рабепразол не оказывал влияния на функцию щитовидной железы, метаболизм углеводов, а также на концентрации в крови паратиреоидного гормона, кортизола, эстрогенов, тестостерона, пролактина, секретина,глюкагона, фолликулостимулирующего гормона, лютеинизирующего гормона, ренина, альдостерона и соматотропного гормона."},{"name":"Фармакологическая группа","value":"ингибиторы протонного насоса"},{"name":"Форма выпуска","value":"таблетки"},{"name":"Способ применения/введения","value":"пероральный"},{"name":"Минимальный возраст применения","value":"от 12 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"При температуре не выше 25 °С. Хранить в недоступном для детей месте."},{"name":"Передозировка","value":"Симптомы. Данные о намеренной или случайной передозировке минимальны. Сообщалось о приеме препарата в дозе 60 мг 2 раза в день или 160 мг однократно, при этом побочные эффекты были минимальны и обратимы и не требовали медицинского вмешательства. Лечение. Специфический антидот для препарата Разо неизвестен. Рабепразол хорошо связывается с белками плазмы, поэтому слабо выводится при диализе. При передозировке необходимо проводить симптоматическое и поддерживающее лечение."},{"name":"Применение при беременности и кормлении грудью","value":"Данных по безопасности применения рабепразола во время беременности нет. Исследования репродуктивности на крысах и кроликах не выявили признаков нарушения фертильности или дефектов развития плода, обусловленных рабепразолом; однако у крыс в небольших количествах препарат проникает через плацентарный барьер. Рабепразол не следует применять при беременности. Неизвестно, выделяется ли рабепразол с грудным молоком. Соответствующие исследования у кормящих женщин не проводились. Вместе с тем рабепразол обнаружен в молоке лактирующих крыс, поэтому препарат нельзя применять в период грудного вскармливания."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Исходя из особенностей фармакодинамики рабепразола и его профиля нежелательных эффектов, маловероятно, что препарат Разо оказывает влияние на способность управлять транспортными средствами и выполнять другие виды деятельности, требующие концентрации внимания и быстроты психомоторных реакций. Однако в случае появления сонливости, головокружения следует избегать этих видов деятельности."},{"name":"Особые указания","value":"Ответ пациента на терапию рабепразолом натрия не исключает наличие злокачественных новообразований в желудке.\u003Cbr\u003E\nДо и после лечения обязателен эндоскопический контроль для исключения злокачественного новообразования, так как лечение может замаскировать симптоматику и отстрочить правильную диагностику. \u003Cbr\u003E\nРекомендуется соблюдать осторожность при первом назначении препарата Разо пациентам с тяжелыми нарушениями функции печени. \u003Cbr\u003E\nПациентам с нарушениями функции почек или печени корректировка дозы препарата Разо не требуется. AUC рабепразола натрия у пациентов с тяжелым нарушением функции печени примерно в два раза выше, чем у здоровых пациентов. \u003Cbr\u003E\nПрепарат не оказывает влияния на функцию щитовидной железы, метаболизм углеводов, на концентрацию в крови паратиреоидного гормона, кортизола, эстрогена, тестостерона, пролактина, холецистокинина, секретина, глюкагона, фолликулостимулирующего гормона, лютеинизирующего гормона, ренина, альдостерона и соматотропного гормона. \u003Cbr\u003E\nСогласно данным наблюдательных исследований терапия ингибиторами протонной помпы может привести к возрастанию риска связанных с остеопорозом переломов бедра, запястья, позвоночника. Риск переломов был увеличен у пациентов, получавших высокие дозы ингибиторов протонной помпы год и более."},{"name":"Взаимодействие","value":"В исследованиях in vitro на микросомах печени человека было показано, что рабепразолметаболизируется в печени изоферментами CYP2C19 и CYP3A4.\u003Cbr\u003E\nРабепразол не вступает в клинически значимые взаимодействия с амоксициллином и с другими лекарственными средствами, метаболизируемыми изоферментами системы цитохрома Р450 в печени: варфарином, фенитоином, теофиллином и диазепамом. \u003Cbr\u003E\nВ связи с тем, что рабепразол вызывает выраженное и длительное снижение выработки соляной кислоты, отмечалось взаимодействие при одновременном приеме с препаратами, абсорбция которых зависит от кислотности содержимого желудка. У здоровых добровольцев прием рабепразола вызывал снижение концентрации кетоконазола в плазме крови на 30% и повышение минимальной концентрации дигоксина на 22%. При одновременном приеме рабепразола с кетоконазолом или дигоксином необходимо корректировать их дозы. \u003Cbr\u003E\nПри одновременном приеме атазанавира 300 мг / ритонавира 100 мг с омепразолом (40 мг 1 раз в день) или с атазанавира 400 мг с лансопразолом (60 мг 1 раз в день) здоровыми добровольцами наблюдалось существенное снижение воздействия атазанавира. Абсорбция атазанавира зависит от pH. Таким образом, не рекомендуется одновременный прием атазанавира с ингибиторами протонного насоса, включая рабепразол. \u003Cbr\u003E\nКонцентрации рабепразола и активного метаболита кларитромицина в плазме крови при одновременном приеме увеличиваются на 24% и 50%, соответственно. Данный эффект используется при проведении эрадикации Helicobacter pylori. \u003Cbr\u003E\nОдновременный прием рабепразола и метотрексата может привести к повышению концентрации метотрексата и его метаболита гидроксиметотрексата и увеличить время их выведения. \u003Cbr\u003E\nНе обнаружено взаимодействия рабепразола с жидкими антацидными препаратами. \u003Cbr\u003E\nНе выявлено клинически значимого взаимодействия рабепразола с пищей."},{"name":"Регистрационный номер","value":"ЛП-002666"},{"name":"Дата государственной регистрации","value":"30.05.2018"},{"name":"Владелец регистрационного удостоверения","value":"Dr. Reddy's Laboratories"},{"name":"Изготовитель","value":"Dr. Reddy's"},{"name":"Фасовщик","value":"Dr. Reddy's"},{"name":"Страна бренда","value":"Индия"},{"name":"Страна-производитель","value":"Индия"},{"name":"Название препарата","value":"Разо"},{"name":"Срок годности","value":"35 мес."}]}],"transitionId":"tr_9935129411001148230"}}}}
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Ещё может подойти

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Инструкция

Показания к применению

- язвенная болезнь желудка в стадии обострения и язва анастомоза;
- язвенная болезнь двенадцатиперстной кишки в стадии обострения;
- эрозивная и язвенная гастроэзофагеальная рефлтоксная болезнь или рефлюкс-эзофагит;
- поддерживающая терапия гастроэзофагеальной рефлюксной болезни;
- неэрозивная гастроэзофагеальная рефлюксная болезнь;
- синдром Золлингера-Эллисона и другие состояния, характеризующиеся патологической гиперсекрецией.
В составе комбинированной терапии:
- эрадикация Helicobacter pylori у пациентов с язвенной болезнью желудка и двенадцатиперстной кишки или хроническим гастритом.

Противопоказания

Повышенная чувствительность к рабепразолу, замещенным бензимидазолам или к вспомогательным компонентам препарата; беременность; период грудного вскармливания (лактации); детский возраст до 12 лет.

Способ применения и дозы

Таблетки принимают внутрь целиком, не разжевывая и не измельчая. Установлено, что ни время суток, ни прием пищи не влияют на активность рабепразола.
При язвенной болезни желудка в стадии обострения и язве анастомоза рекомендуется принимать внутрь по 10 мг или по 20 мг один раз в день. Обычно излечение наступает после 6 недель терапии, однако в некоторых случаях длительность лечения может быть увеличена еще на 6 недель.
При язвенной болезни двенадцатиперстной кишки в стадии обострения рекомендуется принимать внутрь по 20 мг один раз в день. В некоторых случаях лечебный эффект наступает при приеме 10 мг один раз в день. Длительность лечения составляет от 2 до 4 недель. В случае необходимости длительность лечения может быть увеличена еще на 4 недели.
При лечении эрозивной гастроэзофагеальной рефлюксной болезни или рефлюкс-эзофагите рекомендуется принимать внутрь по 10 мг или по 20 мг один раз в день. Длительность лечения составляет от 4 до 8 недель. В случае необходимости длительность лечения может быть увеличена еще на 8 недель.
При поддерживающей терапии гастроэзофагеальной рефлюксной болезни рекомендуется принимать внутрь по 10 мг или по 20 мг один раз в день. Длительность лечения зависит от состояния пациента.
При неэрозивной гастроэзофагеальной рефлюксной болезни рекомендуется принимать внутрь по 10 мг или по 20 мг один раз в день. Если после четырех недель лечения симптомы не исчезают, следует провести дополнительное исследование пациента. После купирования симптомов для предупреждения их последующего возникновения следует принимать препарат внутрь в дозе 10 мг один раз в день.
Для лечения синдрома Золлингера-Эллисона и других состояний, характеризующихся патологической гиперсекрецией дозу подбирают индивидуально. Начальная доза - 60 мг в день, затем дозу повышают и назначают препарат в дозе до 100 мг в день при однократном приеме или по 60 мг два раза в день. Для некоторых пациентов дробное дозирование препарата является предпочтительным. Лечение должно продолжаться по мере клинической необходимости. У некоторых больных с синдромом Золлингера-Эллисона длительность лечения рабепразолом может составлять до одного года.
Для эрадикации Helicobacter pylori рекомендуется принимать внутрь по 20 мг два раза в день по определенной схеме с соответствующей комбинацией антибиотиков. Длительность лечения составляет 7 дней.
Пациенты с почечной и печеночной недостаточностью. Коррекция дозы пациентам с почечной недостаточностью не требуется. У пациентов с легкой и умеренной степенью печеночной недостаточности концентрация рабепразола в крови обычно выше, чем у здоровых пациентов. При назначении препарата Разо пациентам с тяжелой степенью печеночной недостаточности следует соблюдать осторожность.
Дети. Безопасность и эффективность применения рабепразола у детей в возрасте 12 лет и старше установлена для краткосрочного (до 8 недель) лечения ГЭРБ. Рекомендуемая доза для детей в возрасте 12 лет и старше составляет 20 мг 1 раз в день продолжительностью до 8 недель. Безопасность и эффективность рабепразола для применения по другим показаниям не установлена для пациентов детского возраста.
Полная инструкция
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Разо таб. п/о кш/раств.
Разо таб. п/о кш/раств., 10 мг, 15 шт.
4.6
(20)
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1 вопрос
Инструкция

Цена с картой Яндекс Пэй:334 ₽

Скидка: 2%
–2 %
Вместо: 340 ₽
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4.6
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У продавца:20 оценок·8 отзывов
У всех продавцов:81 оценка·37 отзывов
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user avatar
9 месяцев назад • Ирина Николаева • Куплен на Маркете
Достоинства: Помогают, небольшие (легко запиваются), нет аллергической реакции.
Недостатки: Не обнаружены.
Комментарий: Отличные таблетки, помогают при заболеваниях ЖКТ. Гастроэнтеролог прописал годовой курс с перерывом в 2-3 месяца, и данные таблетки входят в каждый курс и всегда помогают, аллергической реакции не выявлено.
user avatar
2 месяца назад • Наталья Черепанова • Куплен на Маркете
Достоинства: Срок годности хороший, упаковка целая
Недостатки: нет
Комментарий: Был назначен как поддерживающая терапия гастроэзофагеальной рефлюксной болезни, со своей задачей справился
user avatar
6 месяцев назад • Александр Старцев • Куплен на Маркете
Достоинства: Понравились таблетки, эффект почувствовал
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    Цена 330 ₽
  • Пензитал Гастро таб. п/о кш/раств., 80 шт.
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1665973179_3/content/content/gallery":{"title":"Пензитал Гастро таб. п/о кш/раств., 80 шт.","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/4571152/img_id6479607919310588143.png/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4571152/img_id6479607919310588143.png/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4571152/img_id6479607919310588143.png/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4571152/img_id6479607919310588143.png/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4571152/img_id6479607919310588143.png/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4571152/img_id6479607919310588143.png/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/1603927/img_id7038205709171817538.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/1603927/img_id7038205709171817538.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/1603927/img_id7038205709171817538.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/1603927/img_id7038205709171817538.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/1603927/img_id7038205709171817538.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/1603927/img_id7038205709171817538.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ2pjSvbf/9Ik5EhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIXCLv3spoGEPqjxMX6Ahje3tAHINrZwQc=","sign":"3Bt2Q3r1cRSTqxyrDPFpW8DPFC/bkNwezMAU/2Aoa7c="},"target":"model_card"},"isNoPicturePadding":true}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1665973179_3/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
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    Пензитал Гастро таб. п/о кш/раств., 80 шт.

    Цена 186 ₽ вместо 188
  • Омез капс. кш/раств., 20 мг, 30 шт.
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    Омез капс. кш/раств., 20 мг, 30 шт.

    Цена 199 ₽
  • Изжогофф таб. жев. мятный, 680 мг + 80 мг, 24 шт., мятный
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    Изжогофф таб. жев. мятный, 680 мг + 80 мг, 24 шт., мятный

    Цена 278 ₽ вместо 281
  • Голдлайн плюс капс., 10 мг+158,5 мг, 10 шт.
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    Голдлайн плюс капс., 10 мг+158,5 мг, 10 шт.

    Цена 702 ₽
  • Vitamin D3, 50000 МЕ, 50 мл, 50 шт.
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    Vitamin D3, 50000 МЕ, 50 мл, 50 шт.

    Цена 1 355 ₽ вместо 1 940
  • Реклама
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    {"widgets":{"@marketfront/CreativeBanner":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_101_8/content/content/content":{"cpcLink":"/safeclick/data=SpQw45JhDGEtO5qMksCMdB2XABugBWM0Asx0Ut01ixXeNy-d_vihX7XjD40b-WQtN9qRbhe6VtsR1cXmuOprn9MFKyEZ0tgxpFwdXufTAhufic-2xct3ubHPNW-Kh-68FU240xx1235P9FLInpDo0DS3HkJ6Qopv4QQKxDtP5magZW4ZPdbs9GJGeCJWXxAaxiraTGnrDiBR4fieWGmEDQGUXTTPHA5m9k6mpUICbxs4yrm0Ik6Md0_UUb-H4b0H5WeLZ-FEyht4zSxF8FMdrvV09GWQq8Z1w-2CPVcURDnQ07ZUwN-q8O4R3iK45YJ_y3drR2DyROtp-rCckNqTwRtYz0y-bzbv6SN3VIIzuKptNed5y8m05exuFNSWJGkmhGlRRNzHvrdBBibgJW1p27BoF7ZcciXGw_gSd9znvIKi0_aw-mN9PEA3H3_gETsD_hM2Sm8BcjzM6INTx5CsYnNOdZByTLhnGifCCDpzUdJiSSMDgAt_YwRIdIfcbvCVfH70W3UN44dpE78N3rBrg1UdWUpP1QVPB9M-hGZgZs7bGi5USjc81OHSq75pTbE-IxGOur97R32S_45JjEJQPodH8ty0HZuohsXITVTcgXPHqHiTY3sFrJYwzsd_-R9eSiVupcHD7-bpeO43YGf18zKF6KBn0GO4Kt2-mrQJJ7tpWgy4pUnozfqDT3L7IAM0zNQp-Q-TTH1cq-bfXmCFrw9YB8efv0tNc1TN3qlOxZZi-hTJLW_M590rgz4DpnuT4SB3GhxZ713BdXvSnTi8rEjdM4QR5a310SsK8rAFY_F8ZIrKxJ4igGgManp5YEpEK5Ov2sF0tKOYpIH72Srh8N_NzpauBPtEiYleg4nbXau6anCZzHa1ex9Fy2jXl9XognNWVKCZfIoAjzMGn_xXTWPO7q_vZZ691sQ4MJbn4d4fMoIUIHeVkodfRg-3qryRoGw3jo1E7NEhFPW5DHiPleMdLxBMJdQnlkVVexxXoh6jIWXIUdFtt8k06xeO7O-84LCt9uCu-DCbIdM-qUvcNvvTcr_SD1qvY2W7VVVQM_ACjezU58JyF8-sYYhEaeYkbXXR-qmtw6305c-Ne11sAWr2dvoxJNvAEAXA62XaXO5uwE_CJ3EqDqslwueYWWEEbzFGUCh0q6Gwe9XI7remcnkjZ5cUz6Jhmzht6bMT6Tws53AcA9NrvIoVpcXU9XncNGmEk6zYxI5u2TyJs95oCaqf3q2Ul6cDqykiJFxz_dH2X7VzUSJQdjbSwXmXMniBxoxrlCbRN5yYBr8XaYL_F1E-jtj43se-BrcXTd7UnF2hFRuM2vZcEc_WScrfvhLVednBOe_J8d08QbfNq8sjc4ikn4fGHPLiMcm6JrQCxz-Gt-59zcLO2vDPjED9NscRkoNecLznC4QZWcrfhYHT9lQT2yZHQmxPLajdzTq8YElwgLHE7H2Z2IxZ6EdDxAMgVKj75O4B0lw5CnWnVjbzxIpOsHgDcZ9-vZVsL3Vm-hlGVKxzpwwEbLJcMA0xoBZdhnX2W_eHkNtsmxEeRmSzjO5QzhHYDSxRJ88pEuGb8VV9GTQek7RR42nkQ7Pn42qMilqJlk5dWp8npWBagZ3L7S6S9KCmOlaJXIi94g42qFK-guBwXts6CfMD5iA7vXYxvQqfuNkaIuduS7Qgl0JHTlz4-UMrya-XGju5IV79MqDI64HLToa9yyScAStvKcxspZUVbtfw1m8Sj5t0yXaQ_YxAWxEol3XemiNJmNY1vQ_HFVsbzvqLhs554Ug04MNw6QZSFsCLSGKTYr_h9VjGclQ4lZBzmDlnPv-FYUAcudxUMeBm-brCgJXbYY61LtyLpbm4b8yqMcD3pHZqiFPi6LhK1Q47k3lw1VT3E-92POOBB241M0d3hKlW0zFv_pq4pz3LOZaUz0_zkrcR08qEylNO3BuBECfiC5hyb5dDzP94iqeNIsU7IoRrCxARSyu60RBeijwpXWhYk2vaLZrFa_jKyMFwtgPoAvHp7Z1qg8LOwUr49DIjPdJ95MtKm31eziM7SiBhFusYZqGMXRbXGUypmwIWE2RknOxi6kN6xt1zmL2FX53hfH951ea2LHfQ94j7f0DeaQmzAs0prsht6EzUzeXjaCiUEcl3SEs4ZApkR3_5PovgykotHYYHXcXS0ayabp_dEIcpPxFd6DaLrkZuA03It7LsjzLcoFE0yr1IyISeuSZUz46u9sOAk1_omrWbbRZs4fxAIsWOxR1yIaQtLZOHnWH9kjG7x_StAI9PfM2lWApSRaMG7lrzFbf11-I8qdyMdED0X4DCrZS_LqDZRC2vGiz3u2Y_lCWA-p4yNFIIewJtHTwZiQUHQFCubJxSdru3PxLRoqsbapRVomhJJcmJzYgP7A50Fa_dKhHRq05vUjx0r7EJNLUVHIzivm_S6KjS23b9IBVKUSujaO9JDmFByVabpWC_CbeHxmLJLNEtNPdzWH4vIZIrwRNuoEMiQNWlNuRyQPa5ikZyBUeNxMK4m48ebKsFjCBknPPGkFs6x4ZaXbddVYQ7NT78u5UxWe2n1PjgSBfQws_3AEujA69dnop3nIk6UImCWyP5M7n39lOPBr7iN5WaxSsa/b64e=1/sign=79117486929fba5db02dade890dbe8f9/keyno=MARKET_1/*","url":"https://market.yandex.ru/promo/tuvio-vacuum?fromSins=1&erid=nyi26TK8Sq2EHejwvAGVPhs7LWBDtuZF","isClickoutExternal":true,"src":"https://avatars.mds.yandex.net/get-market-adv/8781404/cbef35bd-3e50-4bb8-8cbf-1c0bda3d9dff/470x762","srcSet":"https://avatars.mds.yandex.net/get-market-adv/8781404/cbef35bd-3e50-4bb8-8cbf-1c0bda3d9dff/470x762 1x, https://avatars.mds.yandex.net/get-market-adv/8781404/cbef35bd-3e50-4bb8-8cbf-1c0bda3d9dff/940x1524 2x","showUrl":"/safeclick/data=SpQw45JhDGE6zDtOdUQO_Im9wi9o9rqYNedJU5QCZJE3PgVhLwaZ0jFIOD6mDREjOfl_eu3Ryne9PYJ2ZJV1lRchgexssUAvjAA-EnjK8PxJMm-5Jc2D9FIan87OOXK0FO3vUrfrr9Zy2W0_RUbUodNOIVLgDqrBNhPZ6q72z0qpqCFEmJg8HqvuWejJg75W3keI1xrEGWh1rIxHyh7RaSa3WCltSgwXmE-qCS4usMPFkCtGWJAp_S6XtGqDc43FOrWlPHTmO-N-NktZEKFckjyV31wciZCargrnnah8uHvMdpXbMjevZAU24wQjSTVsWAVgBr2ksOXcQQNSHogIsO3zuQby7rT9yKHwj-oliyQK7qnUlt1WDPseEPJGe4AL8c7BFBIIl16BbdCkV_Mi83xDYAax0UnAIhhFKJDHPDVVcWFIKs5veTu8nRuGXViKVReU2TyKHY6rxFHzXtuDZbqyqygaX11x5hPvULxWSom4dIlIdTS995YjyLlWrSpgh9TKRAtIHesbMMzO1NBhgl9dT_t4UV7nLajT_rDY6N4c0vtQKywh09d8wtLA955rXJnTwMvAvb5jFviFBhMmpdVpLSAI7ceeahChbk2KDIwLz2Gma9XlgbPv53Yi_E0xN1pitO6SuHA5VAtrAxBytw68O6ijPA0nNvvtAcB_APzU48gKfVXRZNQNgKwAfykKTHZICOlkeXMgop2dfm-w9VT0rSW6-KLHRmvfhFQVJqsOxpYtgR3ermO8BMcMc3hX8FKJTLwRLsKV5-VJB0LbRQ8pjf83yhJc_Ih2_nvpChaN8imbj1m-25jO6SG5cQGcPkurGjpHzC5mGl2RGL78Z2TzUBQU-xp_cQw40tdPNMvhbxON0UDbI3iERdx7lrZ4WKyiQyHBbKOcMChi38KHWmAAG8Cdg6W_sGYB1CktDlwlZQ8S0rTLc9UYGjRM8HOB4uAZowV3ClG5izegAJKi8cN2ewK0i8KXh6uWp8G1MvqvZ0m8P-uO5wwHK2XuL8il/b64e=1/sign=70715bdbbbd1aada86be02b98671bbd5/keyno=MARKET_1/*","roundedCorners":true,"advertisementId":1856241,"fixedRatio":false,"height":762,"width":470,"billingTargetId":"gg12xjarxwu_1856241","creativeType":"Banner","position":8,"isWhole":true}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_101_8/content/content/content":{"name":"@marketfront/CreativeBanner"}}}
  • Жидкий пластырь Fixplast c пантенолом, 60 мл
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    Жидкий пластырь Fixplast c пантенолом, 60 мл

    Цена 355 ₽ вместо 399
  • ЛимфоТранзит концентрат напитка фл., 100 мл
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1780857920_10/content/content/gallery":{"title":"ЛимфоТранзит концентрат напитка фл., 100 мл","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/4489193/img_id4629792869941954388.png/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4489193/img_id4629792869941954388.png/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4489193/img_id4629792869941954388.png/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4489193/img_id4629792869941954388.png/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4489193/img_id4629792869941954388.png/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4489193/img_id4629792869941954388.png/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/4880383/img_id7613492906357521498.png/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4880383/img_id7613492906357521498.png/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4880383/img_id7613492906357521498.png/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4880383/img_id7613492906357521498.png/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4880383/img_id7613492906357521498.png/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4880383/img_id7613492906357521498.png/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/4012265/img_id719118711323658415.png/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4012265/img_id719118711323658415.png/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4012265/img_id719118711323658415.png/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4012265/img_id719118711323658415.png/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4012265/img_id719118711323658415.png/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4012265/img_id719118711323658415.png/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/4322107/img_id1313108835997666733.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4322107/img_id1313108835997666733.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4322107/img_id1313108835997666733.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4322107/img_id1313108835997666733.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4322107/img_id1313108835997666733.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4322107/img_id1313108835997666733.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ2pjSvbf/9Ik5EhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIWCMD4ltEGEI2Jl7wCGNW7oQYg19zBBw==","sign":"synDhgHW+fhGGPceBp+WmAa6XRuoWzQq/L0rTjY5m6g="},"target":"model_card"},"isNoPicturePadding":true}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1780857920_10/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
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    ЛимфоТранзит концентрат напитка фл., 100 мл

    Цена 332 ₽ вместо 390
  • Пастилки California Gold Nutrition Vitamin D3 gummies со вкусом фруктов и ягод, 280 г, 90 шт.
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    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1780868129_11/content/content/toggleWishlist":{"skuId":"1698969264","productId":1780868129,"offerId":"sd-cpIyDwE5B-YuxcBtYHQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ2pjSvbf/9Ik5EhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIWCKHIl9EGELDtkKoGGN7Q3QYguv/VBw==","sign":"v/f7ZSCkl15TDaZRPNOnZP4rv3nofBBDj3Y3C8gJU2I="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1780868129_11/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Пастилки California Gold Nutrition Vitamin D3 gummies со вкусом фруктов и ягод, 280 г, 90 шт.

    Цена 439 ₽ вместо 443
  • Флексотрон Соло импл. вязкоэластич. стер. для в/суст. ин., 22 мг/мл, 2 мл, 1 шт.
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1778175374_12/content/content/gallery":{"title":"Флексотрон Соло импл. вязкоэластич. стер. для в/суст. ин., 22 мг/мл, 2 мл, 1 шт.","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/4544006/img_id4573924690977915558.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4544006/img_id4573924690977915558.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4544006/img_id4573924690977915558.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4544006/img_id4573924690977915558.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4544006/img_id4573924690977915558.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4544006/img_id4573924690977915558.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/5251502/img_id7830085049915648000.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/5251502/img_id7830085049915648000.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/5251502/img_id7830085049915648000.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/5251502/img_id7830085049915648000.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/5251502/img_id7830085049915648000.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/5251502/img_id7830085049915648000.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ2pjSvbf/9Ik5EhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIWCI6b888GELq15cMDGMGn2Aog59zBBw==","sign":"4SPApmvgV4IZsgRPsL47ZvDbB5MRxkNd4sPGdieTbxY="},"target":"model_card"},"isNoPicturePadding":true}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1778175374_12/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1778175374_12/content/content/toggleWishlist":{"skuId":"947477178","productId":1778175374,"offerId":"QLOf5agZyFClTwbQmI-0bQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ2pjSvbf/9Ik5EhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIWCI6b888GELq15cMDGMGn2Aog59zBBw==","sign":"4SPApmvgV4IZsgRPsL47ZvDbB5MRxkNd4sPGdieTbxY="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1778175374_12/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Флексотрон Соло импл. вязкоэластич. стер. для в/суст. ин., 22 мг/мл, 2 мл, 1 шт.

    Цена 15 939 ₽ вместо 16 100
  • Дюспаталин таб. п/о, 135 мг, 15 шт.
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    Дюспаталин таб. п/о, 135 мг, 15 шт.

    Цена 220 ₽ вместо 222
  • Nutridrink (Nutricia) Compact Protein, готовое к употреблению, 500 мл, 500 г, ваниль, 4 шт.
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    Nutridrink (Nutricia) Compact Protein, готовое к употреблению, 500 мл, 500 г, ваниль, 4 шт.

    Цена 1 314 ₽ вместо 1 327
  • Мезим Форте таб. п/о, 20 шт.
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    Мезим Форте таб. п/о, 20 шт.

    Цена 100 ₽ вместо 101
  • Фестал таб. п/о кш/раств., 40 шт.
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    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1400799455_16/content/content/toggleWishlist":{"skuId":"186858020","productId":1400799455,"offerId":"O_C_K3vMJFqHgANarSt0sQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ2pjSvbf/9Ik5EhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIVCN+B+psFEKT0jFkYqMTeByDa2cEH","sign":"tzPjst/RwPqAgpa+eOONiPvWU4dudfWCZFi2BrweI/A="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1400799455_16/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Фестал таб. п/о кш/раств., 40 шт.

    Цена 316 ₽ вместо 419
  • Хронотрон имплантат инъекц. гель для в/суст. введ., 20 мг/мл, 2 мл, 1 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1778175275_17/content/content/toggleWishlist":{"skuId":"831564747","productId":1778175275,"offerId":"DwKsiI_3skuV5jS1zYZNdw","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ2pjSvbf/9Ik5EhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIWCKua888GEMvXwowDGIqlugQg59zBBw==","sign":"vXBTF1me1Tpgdjlsp7tFn84lxk+vsKoiuXu21ulHgnM="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1778175275_17/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Хронотрон имплантат инъекц. гель для в/суст. введ., 20 мг/мл, 2 мл, 1 шт.

    Цена 9 356 ₽ вместо 9 450
  • Гастрофарм таб., 18 шт.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1400799440_18/content/content/toggleWishlist":{"skuId":"186849724","productId":1400799440,"offerId":"BwPZ_YdLRrk6YG8zhuY5rQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ2pjSvbf/9Ik5EhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIVCNCB+psFELyzjFkY7sLVByDa2cEH","sign":"J2XKz1H9IEb30H3JIeIcsj6LkN7wRFhO4zAprNjBxyY="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1400799440_18/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Гастрофарм таб., 18 шт.

    Цена 365 ₽ вместо 369
  • Липотропный фактор таб. п/о, 1.2 г, 60 шт., 1 уп.
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1778171037_19/content/content/gallery":{"title":"Липотропный фактор таб. п/о, 1.2 г, 60 шт., 1 уп.","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/4866352/img_id7893891243714328834.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4866352/img_id7893891243714328834.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4866352/img_id7893891243714328834.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4866352/img_id7893891243714328834.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4866352/img_id7893891243714328834.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4866352/img_id7893891243714328834.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/4012150/img_id7302244824812547055.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4012150/img_id7302244824812547055.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4012150/img_id7302244824812547055.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4012150/img_id7302244824812547055.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4012150/img_id7302244824812547055.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4012150/img_id7302244824812547055.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ2pjSvbf/9Ik5EhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIVCJ358s8GEP7T0WwY1buhBiDa2cEH","sign":"Na3xpvQI09qbFgHmEWvBbQEZ5k+iRPNKLGmIJ2uIh/A="},"target":"model_card"},"isNoPicturePadding":true}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1778171037_19/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1778171037_19/content/content/toggleWishlist":{"skuId":"227830270","productId":1778171037,"offerId":"23ZXF13sZ25qWtypCZH3kg","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ2pjSvbf/9Ik5EhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIVCJ358s8GEP7T0WwY1buhBiDa2cEH","sign":"Na3xpvQI09qbFgHmEWvBbQEZ5k+iRPNKLGmIJ2uIh/A="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1778171037_19/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Липотропный фактор таб. п/о, 1.2 г, 60 шт., 1 уп.

    Цена 861 ₽ вместо 1 148
  • Де-Нол таб. п/о плен., 120 мг, 32 шт.
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1400799692_20/content/content/gallery":{"title":"Де-Нол таб. п/о плен., 120 мг, 32 шт.","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/6217624/img_id7368554715191948457.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/6217624/img_id7368554715191948457.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/6217624/img_id7368554715191948457.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/6217624/img_id7368554715191948457.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/6217624/img_id7368554715191948457.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/6217624/img_id7368554715191948457.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/3985831/img_id2590614252788234099.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/3985831/img_id2590614252788234099.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/3985831/img_id2590614252788234099.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/3985831/img_id2590614252788234099.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/3985831/img_id2590614252788234099.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/3985831/img_id2590614252788234099.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/5254781/img_id2997095332501512338.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/5254781/img_id2997095332501512338.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/5254781/img_id2997095332501512338.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/5254781/img_id2997095332501512338.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/5254781/img_id2997095332501512338.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/5254781/img_id2997095332501512338.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ2pjSvbf/9Ik5EhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIWCMyD+psFENGLibYCGNDf0Acg2tnBBw==","sign":"yAvWNZ12dMhp9VuTBY1ArHhsjBS8BJuHAwsfJ875YYw="},"target":"model_card"},"isNoPicturePadding":true}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1400799692_20/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1400799692_20/content/content/toggleWishlist":{"skuId":"650266065","productId":1400799692,"offerId":"0H06c2a0CyASMLt_j5lxtQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQ2pjSvbf/9Ik5EhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIWCMyD+psFENGLibYCGNDf0Acg2tnBBw==","sign":"yAvWNZ12dMhp9VuTBY1ArHhsjBS8BJuHAwsfJ875YYw="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1400799692_20/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Де-Нол таб. п/о плен., 120 мг, 32 шт.

    Цена 387 ₽ вместо 438
  • Реклама
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  • Мизол спрей, 50 мл
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    Мизол спрей, 50 мл

    Цена 734 ₽ вместо 815
  • Nutrison (Nutricia) Эдванс, сухая смесь, 332 мл, 322 г, нейтральный
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    Nutrison (Nutricia) Эдванс, сухая смесь, 332 мл, 322 г, нейтральный

    Цена 1 114 ₽ вместо 1 125
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