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Мелатонин-СЗ таб. п/о плен., 3 мг, 30 шт., 1 уп.

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4.6
(24)
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Количество штук в упаковке, шт.: 30

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Коротко о товаре

Артикул Маркета
4611037669
Тип препарата
Назначение
Действующее вещество
Возраст
от 18 лет
Инструкция
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частота неизвестна (по имеющимся данным установить частоту возникновения не представляется возможным).\u003Cbr\u003EИнфекционные и паразитарные заболевания:\u003Cbr\u003Eредко: опоясывающий герпес.\u003Cbr\u003EНарушения со стороны крови и лимфатической системы:\u003Cbr\u003Eредко: лейкопения, тромбоцитопения.\u003Cbr\u003EНарушения со стороны иммунной системы:\u003Cbr\u003Eчастота неизвестна: реакции гиперчувствительности.\u003Cbr\u003EНарушения со стороны обмена веществ и питания:\u003Cbr\u003Eредко: гипертриглицеридемия, гипокалиемия, гипонатриемия.\u003Cbr\u003EНарушения психики:\u003Cbr\u003Eнечасто: раздражительность, нервозность, беспокойство, бессонница, необычные сновидения, ночные кошмары, тревога;\u003Cbr\u003Eредко: перемены настроения, агрессия, ажитация, плаксивость, симптомы стресса, дезориентация, раннее утреннее пробуждение, повышение либидо, сниженное настроение, депрессия.\u003Cbr\u003EНарушения со стороны нервной системы:\u003Cbr\u003Eнечасто: мигрень, головная боль, вялость, психомоторная гиперактивность, головокружение, сонливость;\u003Cbr\u003Eредко: обморок, нарушение памяти, нарушение концентрации внимания, делирий, синдром \"беспокойных ног\", плохое качество сна, парестезии.\u003Cbr\u003EНарушения со стороны органа зрения:\u003Cbr\u003Eредко: снижение остроты зрения, нечеткость зрения, повышенное слезотечение.\u003Cbr\u003EНарушения со стороны органа слуха и лабиринтные нарушения:\u003Cbr\u003Eредко: вертиго, позиционное вертиго.\u003Cbr\u003EНарушения со стороны сердечно-сосудистой системы:\u003Cbr\u003Eнечасто: артериальная гипертензия;\u003Cbr\u003Eредко: стенокардия напряжения, ощущение сердцебиения, приливы.\u003Cbr\u003EНарушения со стороны желудочно-кишечного тракта:\u003Cbr\u003Eнечасто: абдоминальная боль, абдоминальная боль в верхней части живота, диспепсия, язвенный стоматит, сухость во рту, тошнота;\u003Cbr\u003Eредко: гастроэзофагеальная болезнь, желудочно-кишечное нарушение или расстройство, буллезный стоматит, язвенный глоссит, рвота, усиление перистальтики, вздутие живота, гиперсекреция слюны, неприятный запах изо рта, абдоминальный дискомфорт, дискинезия желудка, гастрит.\u003Cbr\u003EНарушения со стороны печени и желчевыводящих путей:\u003Cbr\u003Eнечасто: гипербилирубинемия.\u003Cbr\u003EНарушения со стороны кожи и подкожных тканей:\u003Cbr\u003Eнечасто: дерматит, потливость по ночам, зуд и генерализованный зуд, сыпь, сухость кожи;\u003Cbr\u003Eредко: экзема, эритема, дерматит рук, псориаз, генерализованная сыпь, зудящая сыпь, поражение ногтей;\u003Cbr\u003Eчастота неизвестна: отек Квинке, отек слизистой оболочки полости рта, отек языка.\u003Cbr\u003EНарушения со стороны скелетно-мышечной и соединительной ткани:\u003Cbr\u003Eнечасто: боль в конечностях;\u003Cbr\u003Eредко: артрит, мышечный спазм, боль в шее, ночные судороги.\u003Cbr\u003EНарушения со стороны почек и мочевыводящих путей:\u003Cbr\u003Eнечасто: глюкозурия, протеинурия;\u003Cbr\u003Eредко: полиурия, гематурия, никтурия.\u003Cbr\u003EНарушения со стороны половых органов и грудной железы:\u003Cbr\u003Eнечасто: менопаузальные симптомы; редко: приапизм, простатит;\u003Cbr\u003Eчастота неизвестна: галакторея.\u003Cbr\u003EОбщие расстройства и нарушения в месте введения:\u003Cbr\u003Eнечасто: астения, боль в груди;\u003Cbr\u003Eредко: утомляемость, боль, жажда."},{"name":"Фармакологическое действие","value":"Синтетический аналог гормона шишковидного тела (эпифиза); оказывает адаптогенное, седативное, снотворное действие. Нормализует циркадные ритмы. Увеличивает концентрацию гамма-аминомасляной кислоты (ГАМК) и серотонина в среднем мозге и гипоталамусе, изменяет активность пиридоксалькиназы, участвующей в синтезе ГАМК, дофамина и серотонина. Регулирует цикл сон-бодрствование, суточные изменения локомоторной активности и температуры тела, положительно влияет на интеллектуально-мнестические функции мозга, на эмоционально-личностную сферу. Способствует организации биологического ритма и нормализации ночного сна. Улучшает качество сна, ускоряет засыпание, регулирует нейроэндокринные функции. Адаптирует организм метеочувствительных людей к изменениям погодных условий."},{"name":"Фармакологическая группа","value":"адаптогенное средство"},{"name":"Форма выпуска","value":"таблетки, покрытые пленочной оболочкой"},{"name":"Способ применения/введения","value":"пероральный","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["35947170:36763744"]}}},{"name":"Минимальный возраст применения","value":"от 18 лет"},{"name":"Условия хранения","value":"В защищенном от света месте, при температуре не выше 25 °С. Хранить в недоступном для детей месте."},{"name":"Передозировка","value":"По имеющимся литературным данным, применение мелатонина в суточной дозе до 300 мг не вызывало клинически значимых нежелательных реакций. Наблюдались гиперемия, спазмы в брюшной полости, диарея, головная боль и скотома при применении мелатонина в дозах 3000-6600 мг в течение нескольких недель. При применении очень высоких доз мелатонина (до 1 г) наблюдалась непроизвольная потеря сознания.\u003Cbr\u003EПри передозировке возможно развитие сонливости.\u003Cbr\u003EЛечение - промывание желудка и применение активированного угля, симптоматическая терапия.\u003Cbr\u003EКлиренс активного вещества предполагается в пределах 12 часов после приема внутрь."},{"name":"Применение при беременности и кормлении грудью","value":"Препарат противопоказан к применению при беременности и в период грудного вскармливания."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Препарат Мелатонин-СЗ вызывает сонливость, в связи с этим в период лечения следует воздержаться от вождения автотранспорта и занятий потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."},{"name":"Особые указания","value":"В период применения препарата Мелатонин-СЗ рекомендуется избегать пребывания на ярком свету.\u003Cbr\u003EНеобходимо проинформировать женщин, желающих забеременеть, о наличии у препарата слабого контрацептивного действия.\u003Cbr\u003EОтсутствуют клинические данные о применении мелатонина у больных с аутоиммунными заболеваниями, в связи с чем применение у данной категории пациентов не рекомендуется.\u003Cbr\u003EС осторожностью:\u003Cbr\u003EПрепарат Мелатонин-СЗ нужно применять с осторожностью пациентам с различной степенью почечной недостаточности.\u003Cbr\u003EСледует соблюдать осторожность в отношении пациентов, принимающих флувоксамин, который повышает концентрацию мелатонина за счет ингибирования его метаболизма изоферментами цитохрома Р450 (CYP): CYP1A2 и CYP2C19. Следует избегать такой комбинации.\u003Cbr\u003E Следует соблюдать осторожность в отношении пациентов, принимающих 5- и 8-метоксипсорален, который повышает концентрацию мелатонина вследствие ингибирования его метаболизма.\u003Cbr\u003EСледует соблюдать осторожность в отношении пациентов, принимающих циметидин, поскольку он повышает содержание мелатонина в плазме за счет ингибирования последнего.\u003Cbr\u003EСледует соблюдать осторожность в отношении пациентов, принимающих эстрогены (например, контрацептивы или заместительную гормональную терапию), которые увеличивают концентрацию мелатонина путем ингибирования их метаболизма изоферментами CYP1А1 и CYP1A2."},{"name":"Взаимодействие","value":"Фармакокинетическое взаимодействие\u003Cbr\u003E- Известно, что в концентрациях, значительно превышающих терапевтические, мелатонин индуцирует изофермент CYP3A in vitro. Клиническое значение этого явления до конца не выяснено. В случае развития признаков индукции следует рассмотреть вопрос о снижении дозы одновременно применяемых лекарственных средств.\u003Cbr\u003E- В концентрациях, значительно превышающих терапевтические, мелатонин не индуцирует изоферменты группы CYP1A in vitro. Следовательно, взаимодействие мелатонина с другими лекарственными средствами вследствие влияния мелатонина на изоферменты группы CYP1A, по-видимому, незначимо.\u003Cbr\u003E- Метаболизм мелатонина, главным образом, опосредован изоферментами CYP1A. Следовательно, возможно взаимодействие мелатонина с другими лекарственными средствами вследствие влияния мелатонина на изоферменты группы CYP1 А.\u003Cbr\u003E-Курение способно снизить концентрацию мелатонина за счет индукции изофермента CYP1A2.\u003Cbr\u003E- Ингибиторы изоферментов CYPA2, например, хинолоны, способны повышать экспозицию мелатонина.\u003Cbr\u003E- Индукторы изофермента CYP1A2, такие как карбамазепин и рифампицин, способны снижать плазменную концентрацию мелатонина.\u003Cbr\u003E- В современной литературе имеется множество данных, касающихся влияния агонистов/антагонистов адренергических и опиоидных рецепторов, антидепрессантов, ингибиторов простагландинов, бензодиазепинов, триптофана и алкоголя на секрецию эндогенного мелатонина. Исследования взаимного влияния этих препаратов на динамику или кинетику мелатонина не проводилось.\u003Cbr\u003EФармакодинамическое взаимодействие\u003Cbr\u003E- Во время приема мелатонина не следует употреблять алкоголь, так как он снижает эффективность препарата.\u003Cbr\u003E- Мелатонин потенцирует седативное действие бензодиазепиновых и небензодиазепиновых снотворных средств, таких как залеплон, золпидем и зопиклон. В ходе клинического исследования наблюдались четкие признаки транзиторного фармакодинамического взаимодействия между мелатонином и золпидемом спустя час после их приема. Комбинированное применение может приводить к прогрессирующему расстройству внимания, памяти и координации в сравнении с монотерапией золпидемом.\u003Cbr\u003E- В ходе исследований мелатонин назначался совместно с тиоридазином и имипрамином, препаратами, которые влияют па центральную нервную систему. Ни в одном из случаев не было выявлено клинически значимого фармакокинетического взаимодействия. Тем не менее, одновременное применение с мелатонином приводило к повышению ощущения спокойствия и к затруднениям в выполнении определенных заданий в сравнении с монотерапией имипрамином, а также к усилению чувства \"помутнения в голове\", в сравнении с монотерапией тиоридазином."},{"name":"Регистрационный номер","value":"ЛП-004758"},{"name":"Дата государственной регистрации","value":"13.05.2019"},{"name":"Владелец регистрационного удостоверения","value":"Северная Звезда","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["34324371:35649313","7893318:16002862"]}}},{"name":"Изготовитель","value":"Северная Звезда"},{"name":"Фасовщик","value":"Северная Звезда"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Мелатонин-СЗ","transition":{"type":"catalog","params":{"categorySlug":"sredstva-dlia-nervnoi-sistemy","categoryId":"15756525","navnodeId":"72478","glfilters":["17796364:18023779"]}}},{"name":"Срок годности","value":"35 мес."}]}},"fullSpecsGrouped":{"8770727216810445252":{"groups":[{"name":"Общие характеристики","items":[{"name":"Тип препарата","value":"лекарственный препарат"},{"name":"Органы и системы","value":"нервная система"},{"name":"Назначение","value":"бессонница, десинхроноз, нарушение сна"},{"name":"Показания к применению","value":"При расстройстве сна, в т.ч. обусловленных нарушением ритма \"сон- бодрствование\", таких как десинхроноз (резкая смена часовых поясов)."},{"name":"Противопоказания","value":"Гиперчувствительность к компонентам препарата, аутоиммунные заболевания, печеночная недостаточность, тяжелая почечная недостаточность, беременность, период грудного вскармливания, детский возраст до 18 лет."},{"name":"Состав","value":"1 таблетка содержит:\u003Cbr\u003Eдействующее вещество: мелатонин - 3 мг\u003Cbr\u003Eвспомогательные вещества: целлюлоза микрокристаллическая 102 - 48,5 мг; карбоксиметилкрахмал натрия - 6,5 мг; кальция гидрофосфата дигидрат - 41,0 мг; магния стеарат - 1,0 мг\u003Cbr\u003Eсостав оболочки: гипромеллоза - 1,53 мг; полисорбат-80 (твин-80) - 0,64 мг; тальк - 0,51 мг; титана диоксид Е 171 - 0,32 мг."},{"name":"Действующее вещество","value":"Мелатонин"},{"name":"Способ применения и дозы","value":"Внутрь.\u003Cbr\u003EПри нарушении сна - по 3 мг один раз в сутки за 30-40 минут до сна.\u003Cbr\u003EПри десинхронозе в качестве адаптогена при смене часовых поясов - за 1 день до перелета и в последующие 2-5 дней - по 3 мг за 30-40 минут до сна.\u003Cbr\u003EМаксимальная суточная доза - 6 мг.\u003Cbr\u003EПожилые пациенты\u003Cbr\u003EС возрастом происходит снижение метаболизма мелатонина, что необходимо учитывать при выборе режима дозирования для пожилых пациентов.\u003Cbr\u003EС учетом этого у пациентов пожилого возраста, возможен прием препарата за 60-90 минут до сна.\u003Cbr\u003EПациентам с тяжелой почечной недостаточностью применение препарата не рекомендуется."},{"name":"Побочные действия","value":"Классификация частоты развития побочных эффектов согласно рекомендациям Всемирной Организации Здравоохранения: очень часто (≥1/10), часто (от ≥1/100 до \u003C1/10), нечасто (от ≥1/1000 до \u003C1/100), редко (от ≥1/10000 до \u003C1/1000), очень редко (\u003C 1/10000), включая отдельные сообщения; частота неизвестна (по имеющимся данным установить частоту возникновения не представляется возможным).\u003Cbr\u003EИнфекционные и паразитарные заболевания:\u003Cbr\u003Eредко: опоясывающий герпес.\u003Cbr\u003EНарушения со стороны крови и лимфатической системы:\u003Cbr\u003Eредко: лейкопения, тромбоцитопения.\u003Cbr\u003EНарушения со стороны иммунной системы:\u003Cbr\u003Eчастота неизвестна: реакции гиперчувствительности.\u003Cbr\u003EНарушения со стороны обмена веществ и питания:\u003Cbr\u003Eредко: гипертриглицеридемия, гипокалиемия, гипонатриемия.\u003Cbr\u003EНарушения психики:\u003Cbr\u003Eнечасто: раздражительность, нервозность, беспокойство, бессонница, необычные сновидения, ночные кошмары, тревога;\u003Cbr\u003Eредко: перемены настроения, агрессия, ажитация, плаксивость, симптомы стресса, дезориентация, раннее утреннее пробуждение, повышение либидо, сниженное настроение, депрессия.\u003Cbr\u003EНарушения со стороны нервной системы:\u003Cbr\u003Eнечасто: мигрень, головная боль, вялость, психомоторная гиперактивность, головокружение, сонливость;\u003Cbr\u003Eредко: обморок, нарушение памяти, нарушение концентрации внимания, делирий, синдром \"беспокойных ног\", плохое качество сна, парестезии.\u003Cbr\u003EНарушения со стороны органа зрения:\u003Cbr\u003Eредко: снижение остроты зрения, нечеткость зрения, повышенное слезотечение.\u003Cbr\u003EНарушения со стороны органа слуха и лабиринтные нарушения:\u003Cbr\u003Eредко: вертиго, позиционное вертиго.\u003Cbr\u003EНарушения со стороны сердечно-сосудистой системы:\u003Cbr\u003Eнечасто: артериальная гипертензия;\u003Cbr\u003Eредко: стенокардия напряжения, ощущение сердцебиения, приливы.\u003Cbr\u003EНарушения со стороны желудочно-кишечного тракта:\u003Cbr\u003Eнечасто: абдоминальная боль, абдоминальная боль в верхней части живота, диспепсия, язвенный стоматит, сухость во рту, тошнота;\u003Cbr\u003Eредко: гастроэзофагеальная болезнь, желудочно-кишечное нарушение или расстройство, буллезный стоматит, язвенный глоссит, рвота, усиление перистальтики, вздутие живота, гиперсекреция слюны, неприятный запах изо рта, абдоминальный дискомфорт, дискинезия желудка, гастрит.\u003Cbr\u003EНарушения со стороны печени и желчевыводящих путей:\u003Cbr\u003Eнечасто: гипербилирубинемия.\u003Cbr\u003EНарушения со стороны кожи и подкожных тканей:\u003Cbr\u003Eнечасто: дерматит, потливость по ночам, зуд и генерализованный зуд, сыпь, сухость кожи;\u003Cbr\u003Eредко: экзема, эритема, дерматит рук, псориаз, генерализованная сыпь, зудящая сыпь, поражение ногтей;\u003Cbr\u003Eчастота неизвестна: отек Квинке, отек слизистой оболочки полости рта, отек языка.\u003Cbr\u003EНарушения со стороны скелетно-мышечной и соединительной ткани:\u003Cbr\u003Eнечасто: боль в конечностях;\u003Cbr\u003Eредко: артрит, мышечный спазм, боль в шее, ночные судороги.\u003Cbr\u003EНарушения со стороны почек и мочевыводящих путей:\u003Cbr\u003Eнечасто: глюкозурия, протеинурия;\u003Cbr\u003Eредко: полиурия, гематурия, никтурия.\u003Cbr\u003EНарушения со стороны половых органов и грудной железы:\u003Cbr\u003Eнечасто: менопаузальные симптомы; редко: приапизм, простатит;\u003Cbr\u003Eчастота неизвестна: галакторея.\u003Cbr\u003EОбщие расстройства и нарушения в месте введения:\u003Cbr\u003Eнечасто: астения, боль в груди;\u003Cbr\u003Eредко: утомляемость, боль, жажда."},{"name":"Фармакологическое действие","value":"Синтетический аналог гормона шишковидного тела (эпифиза); оказывает адаптогенное, седативное, снотворное действие. Нормализует циркадные ритмы. Увеличивает концентрацию гамма-аминомасляной кислоты (ГАМК) и серотонина в среднем мозге и гипоталамусе, изменяет активность пиридоксалькиназы, участвующей в синтезе ГАМК, дофамина и серотонина. Регулирует цикл сон-бодрствование, суточные изменения локомоторной активности и температуры тела, положительно влияет на интеллектуально-мнестические функции мозга, на эмоционально-личностную сферу. Способствует организации биологического ритма и нормализации ночного сна. Улучшает качество сна, ускоряет засыпание, регулирует нейроэндокринные функции. Адаптирует организм метеочувствительных людей к изменениям погодных условий."},{"name":"Фармакологическая группа","value":"адаптогенное средство"},{"name":"Форма выпуска","value":"таблетки, покрытые пленочной оболочкой"},{"name":"Способ применения/введения","value":"пероральный"},{"name":"Минимальный возраст применения","value":"от 18 лет"}]},{"name":"Дополнительно","items":[{"name":"Условия хранения","value":"В защищенном от света месте, при температуре не выше 25 °С. Хранить в недоступном для детей месте."},{"name":"Передозировка","value":"По имеющимся литературным данным, применение мелатонина в суточной дозе до 300 мг не вызывало клинически значимых нежелательных реакций. Наблюдались гиперемия, спазмы в брюшной полости, диарея, головная боль и скотома при применении мелатонина в дозах 3000-6600 мг в течение нескольких недель. При применении очень высоких доз мелатонина (до 1 г) наблюдалась непроизвольная потеря сознания.\u003Cbr\u003EПри передозировке возможно развитие сонливости.\u003Cbr\u003EЛечение - промывание желудка и применение активированного угля, симптоматическая терапия.\u003Cbr\u003EКлиренс активного вещества предполагается в пределах 12 часов после приема внутрь."},{"name":"Применение при беременности и кормлении грудью","value":"Препарат противопоказан к применению при беременности и в период грудного вскармливания."},{"name":"Влияние на способность управлять транспортом и механизмами","value":"Препарат Мелатонин-СЗ вызывает сонливость, в связи с этим в период лечения следует воздержаться от вождения автотранспорта и занятий потенциально опасными видами деятельности, требующими повышенной концентрации внимания и быстроты психомоторных реакций."},{"name":"Особые указания","value":"В период применения препарата Мелатонин-СЗ рекомендуется избегать пребывания на ярком свету.\u003Cbr\u003EНеобходимо проинформировать женщин, желающих забеременеть, о наличии у препарата слабого контрацептивного действия.\u003Cbr\u003EОтсутствуют клинические данные о применении мелатонина у больных с аутоиммунными заболеваниями, в связи с чем применение у данной категории пациентов не рекомендуется.\u003Cbr\u003EС осторожностью:\u003Cbr\u003EПрепарат Мелатонин-СЗ нужно применять с осторожностью пациентам с различной степенью почечной недостаточности.\u003Cbr\u003EСледует соблюдать осторожность в отношении пациентов, принимающих флувоксамин, который повышает концентрацию мелатонина за счет ингибирования его метаболизма изоферментами цитохрома Р450 (CYP): CYP1A2 и CYP2C19. Следует избегать такой комбинации.\u003Cbr\u003E Следует соблюдать осторожность в отношении пациентов, принимающих 5- и 8-метоксипсорален, который повышает концентрацию мелатонина вследствие ингибирования его метаболизма.\u003Cbr\u003EСледует соблюдать осторожность в отношении пациентов, принимающих циметидин, поскольку он повышает содержание мелатонина в плазме за счет ингибирования последнего.\u003Cbr\u003EСледует соблюдать осторожность в отношении пациентов, принимающих эстрогены (например, контрацептивы или заместительную гормональную терапию), которые увеличивают концентрацию мелатонина путем ингибирования их метаболизма изоферментами CYP1А1 и CYP1A2."},{"name":"Взаимодействие","value":"Фармакокинетическое взаимодействие\u003Cbr\u003E- Известно, что в концентрациях, значительно превышающих терапевтические, мелатонин индуцирует изофермент CYP3A in vitro. Клиническое значение этого явления до конца не выяснено. В случае развития признаков индукции следует рассмотреть вопрос о снижении дозы одновременно применяемых лекарственных средств.\u003Cbr\u003E- В концентрациях, значительно превышающих терапевтические, мелатонин не индуцирует изоферменты группы CYP1A in vitro. Следовательно, взаимодействие мелатонина с другими лекарственными средствами вследствие влияния мелатонина на изоферменты группы CYP1A, по-видимому, незначимо.\u003Cbr\u003E- Метаболизм мелатонина, главным образом, опосредован изоферментами CYP1A. Следовательно, возможно взаимодействие мелатонина с другими лекарственными средствами вследствие влияния мелатонина на изоферменты группы CYP1 А.\u003Cbr\u003E-Курение способно снизить концентрацию мелатонина за счет индукции изофермента CYP1A2.\u003Cbr\u003E- Ингибиторы изоферментов CYPA2, например, хинолоны, способны повышать экспозицию мелатонина.\u003Cbr\u003E- Индукторы изофермента CYP1A2, такие как карбамазепин и рифампицин, способны снижать плазменную концентрацию мелатонина.\u003Cbr\u003E- В современной литературе имеется множество данных, касающихся влияния агонистов/антагонистов адренергических и опиоидных рецепторов, антидепрессантов, ингибиторов простагландинов, бензодиазепинов, триптофана и алкоголя на секрецию эндогенного мелатонина. Исследования взаимного влияния этих препаратов на динамику или кинетику мелатонина не проводилось.\u003Cbr\u003EФармакодинамическое взаимодействие\u003Cbr\u003E- Во время приема мелатонина не следует употреблять алкоголь, так как он снижает эффективность препарата.\u003Cbr\u003E- Мелатонин потенцирует седативное действие бензодиазепиновых и небензодиазепиновых снотворных средств, таких как залеплон, золпидем и зопиклон. В ходе клинического исследования наблюдались четкие признаки транзиторного фармакодинамического взаимодействия между мелатонином и золпидемом спустя час после их приема. Комбинированное применение может приводить к прогрессирующему расстройству внимания, памяти и координации в сравнении с монотерапией золпидемом.\u003Cbr\u003E- В ходе исследований мелатонин назначался совместно с тиоридазином и имипрамином, препаратами, которые влияют па центральную нервную систему. Ни в одном из случаев не было выявлено клинически значимого фармакокинетического взаимодействия. Тем не менее, одновременное применение с мелатонином приводило к повышению ощущения спокойствия и к затруднениям в выполнении определенных заданий в сравнении с монотерапией имипрамином, а также к усилению чувства \"помутнения в голове\", в сравнении с монотерапией тиоридазином."},{"name":"Регистрационный номер","value":"ЛП-004758"},{"name":"Дата государственной регистрации","value":"13.05.2019"},{"name":"Владелец регистрационного удостоверения","value":"Северная Звезда"},{"name":"Изготовитель","value":"Северная Звезда"},{"name":"Фасовщик","value":"Северная Звезда"},{"name":"Страна бренда","value":"Россия"},{"name":"Страна-производитель","value":"Россия"},{"name":"Название препарата","value":"Мелатонин-СЗ"},{"name":"Срок годности","value":"35 мес."}]}],"transitionId":"tr_7540901054708843823"}}}}
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Цена с картой Яндекс Пэй:403 ₽

Скидка: 2%
–2 %
Вместо: 411 ₽
  • 12 июня, курьер Маркета • 249 ₽
POLZAru
Рейтинг 4.9 из 5
38Котзывов
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Инструкция

Показания к применению

При расстройстве сна, в т.ч. обусловленных нарушением ритма "сон- бодрствование", таких как десинхроноз (резкая смена часовых поясов).

Противопоказания

Гиперчувствительность к компонентам препарата, аутоиммунные заболевания, печеночная недостаточность, тяжелая почечная недостаточность, беременность, период грудного вскармливания, детский возраст до 18 лет.

Способ применения и дозы

Внутрь.
При нарушении сна - по 3 мг один раз в сутки за 30-40 минут до сна.
При десинхронозе в качестве адаптогена при смене часовых поясов - за 1 день до перелета и в последующие 2-5 дней - по 3 мг за 30-40 минут до сна.
Максимальная суточная доза - 6 мг.
Пожилые пациенты
С возрастом происходит снижение метаболизма мелатонина, что необходимо учитывать при выборе режима дозирования для пожилых пациентов.
С учетом этого у пациентов пожилого возраста, возможен прием препарата за 60-90 минут до сна.
Пациентам с тяжелой почечной недостаточностью применение препарата не рекомендуется.
Полная инструкция
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Мелатонин-СЗ таб. п/о плен.
Мелатонин-СЗ таб. п/о плен., 3 мг, 30 шт., 1 уп.
4.6
(24)
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15 вопросов
Инструкция

Цена с картой Яндекс Пэй:336 ₽

Скидка: 1%
–1 %
Вместо: 339 ₽
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4.6
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У продавца:24 оценки·7 отзывов
У всех продавцов:479 оценок·187 отзывов
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user avatar
Месяц назад • Имя скрыто • Куплен на Маркете
Достоинства: Препарат точно действует,э. Взяла, так как нарушены ритмы сна, которые пагубно влияют на здоровье. После приёма через какое то время тянет в сон, но если упорно продолжать смотреть телевизор или смотреть в телефон, то не получится уснуть, обязательно должно быть темно.
Недостатки: лично мне не подошёл, так как после приёма фазы быстрого сна становится больше и из-за этого снятся кошмары, просыпаюсь часто среди ночи, это говорит о том, что мне нужна дозировка поменьше, начинать лучше с 0,5 мг)
Комментарий: Муж испробовал на себе, так как тоже ложится очень поздно, а вставать на работу рано, ему препарат подошёл. Раньше он и за ночь раз 5 мог проснуться и сходить в туалет, из-за чего тоже не высыпался. После первого приёма он уснул быстро, как рассчитывал и за ночь проснулся лишь 1 раз, впервые за долгое время выспался. Но не принимайте препарат часто, лишь в те дни, когда это необходимо! Он может плохо повлиять на ваш организм , приводя к дальнейшему нарушению сна и даже раку. Всем здоровья)
user avatar
6 дней назад • Вольтер Догман. • Куплен на Маркете
Достоинства: Действуют как мне кажется даже лучше предыдущих которые в аптеке покупал
Недостатки: Не заметил,дозировку нужно подбирать индивидуально
Комментарий: Все подошло устроило,качество хорошее
user avatar
2 недели назад • светлана ф • Куплен на Маркете
Достоинства: Супер
Недостатки: Нет
Комментарий: Буду постоянно
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    Цена 359 ₽ вместо 363
  • Мелаксен таб., 3 мг, 24 шт.
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    Мелаксен таб., 3 мг, 24 шт.

    Цена 722 ₽ вместо 729
  • Глицин+Мелатонин Эвалар таб. п/языч., 20 шт.
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    Глицин+Мелатонин Эвалар таб. п/языч., 20 шт.

    Цена 743 ₽ вместо 816
  • Vitamin D3, 50000 МЕ, 50 мл, 50 шт.
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    Vitamin D3, 50000 МЕ, 50 мл, 50 шт.

    Цена 1 355 ₽ вместо 1 940
  • Omega-3 капс., 1000 мг, 100 мл, 30 шт.
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    Omega-3 капс., 1000 мг, 100 мл, 30 шт.

    Цена 446 ₽ вместо 450
  • Пастилки California Gold Nutrition Vitamin D3 gummies со вкусом фруктов и ягод, 280 г, 90 шт.
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    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1780868129_5/content/content/toggleWishlist":{"skuId":"1698969264","productId":1780868129,"offerId":"sd-cpIyDwE5B-YuxcBtYHQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQuuuOyc6VivQ1EhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIWCKHIl9EGELDtkKoGGN7Q3QYguv/VBw==","sign":"RnTL1CdnK8OTlCdJrz+O53kIBZX/Y29VIE1gFUDDbI0="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1780868129_5/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Пастилки California Gold Nutrition Vitamin D3 gummies со вкусом фруктов и ягод, 280 г, 90 шт.

    Цена 439 ₽ вместо 443
  • Соннован таб. п/о плен., 3 мг, 30 шт.
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1404748622_6/content/content/gallery":{"title":"Соннован таб. п/о плен., 3 мг, 30 шт.","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/4346078/img_id6252837170548514842.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4346078/img_id6252837170548514842.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4346078/img_id6252837170548514842.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4346078/img_id6252837170548514842.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4346078/img_id6252837170548514842.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4346078/img_id6252837170548514842.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/7888310/img_id8109801689953884094.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/7888310/img_id8109801689953884094.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/7888310/img_id8109801689953884094.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/7888310/img_id8109801689953884094.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/7888310/img_id8109801689953884094.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/7888310/img_id8109801689953884094.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/4367383/img_id4375867665913428253.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4367383/img_id4375867665913428253.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4367383/img_id4375867665913428253.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4367383/img_id4375867665913428253.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4367383/img_id4375867665913428253.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4367383/img_id4375867665913428253.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/4466428/img_id2090121862389354021.png/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4466428/img_id2090121862389354021.png/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4466428/img_id2090121862389354021.png/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4466428/img_id2090121862389354021.png/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4466428/img_id2090121862389354021.png/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4466428/img_id2090121862389354021.png/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQuuuOyc6VivQ1EhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIVCM6G650FEIW+4GwY6vqGESDt2cEH","sign":"CCSnGlirKH8kRhLJa3ttCKmYwsciLjsAylhs4AXYAoU="},"target":"model_card"},"isNoPicturePadding":true}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1404748622_6/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1404748622_6/content/content/toggleWishlist":{"skuId":"228073221","productId":1404748622,"offerId":"-e4ap0nfs4PkE5OHOqmmfQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQuuuOyc6VivQ1EhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIVCM6G650FEIW+4GwY6vqGESDt2cEH","sign":"CCSnGlirKH8kRhLJa3ttCKmYwsciLjsAylhs4AXYAoU="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1404748622_6/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Соннован таб. п/о плен., 3 мг, 30 шт.

    Цена 397 ₽ вместо 401
  • Мелатонин таб. п/о плен., 3 мг, 30 шт., 1 уп.
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1664457252_7/content/content/toggleWishlist":{"skuId":"101606729738","productId":1664457252,"offerId":"4cPOfb3jL-5oO4dVRPVUGQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQuuuOyc6VivQ1EhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIXCKS01pkGEIrQ7sH6AhjX8c8GIO3ZwQc=","sign":"YemeVnhvGKX6TVPtVLhadtHFUc5ymsg++nXHG16DFtM="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1664457252_7/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Мелатонин таб. п/о плен., 3 мг, 30 шт., 1 уп.

    Цена 483 ₽ вместо 488
  • Реклама
    {"widgets":{"@light/AdLabel":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_101_8/content/content/content/adLabel":{"adLabel":{"adLabelText":"Реклама","advertizer":"МАРКЕТ.ТРЕЙД, ИНН 9705171890, ID #e-1g-101880-VND-ADV","adLabel":1},"advertisementId":1641961,"allowDebug":false,"borderRadius":5,"indents":6}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_101_8/content/content/content/adLabel":{"name":"@light/AdLabel"}}}
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  • Велсон таб. п/о плен., 3 мг, 30 шт.
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    Велсон таб. п/о плен., 3 мг, 30 шт.

    Цена 592 ₽
  • ЛимфоТранзит концентрат напитка фл., 100 мл
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    ЛимфоТранзит концентрат напитка фл., 100 мл

    Цена 332 ₽ вместо 390
  • БиоГая Пробиотик капли детск. фл., 5 мл, 1 уп.
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:997279548_11/content/content/gallery":{"title":"БиоГая Пробиотик капли детск. фл., 5 мл, 1 уп.","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/5131700/img_id5468924246027050142.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/5131700/img_id5468924246027050142.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/5131700/img_id5468924246027050142.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/5131700/img_id5468924246027050142.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/5131700/img_id5468924246027050142.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/5131700/img_id5468924246027050142.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/4408567/img_id147222889702037708.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4408567/img_id147222889702037708.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4408567/img_id147222889702037708.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4408567/img_id147222889702037708.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4408567/img_id147222889702037708.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4408567/img_id147222889702037708.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQuuuOyc6VivQ1EhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIXCLyOxdsDEPTRh9H5Ahj03/kHINrZwQc=","sign":"sNzMEj0zbJvZxJ5hGeVOK76C7gWErjzTAzTTuGu+p3k="},"target":"model_card"},"isNoPicturePadding":true}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:997279548_11/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
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    БиоГая Пробиотик капли детск. фл., 5 мл, 1 уп.

    Цена 2 025 ₽ вместо 3 500
  • Гармония сна капс., 0.36 г
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    Гармония сна капс., 0.36 г

    Цена 341 ₽ вместо 742
  • Сонные+ таб., 30 шт., 1 уп.
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    Сонные+ таб., 30 шт., 1 уп.

    Цена 275 ₽ вместо 399
  • Табекс таб. п/о плен., 1.5 мг, 100 шт.
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    Табекс таб. п/о плен., 1.5 мг, 100 шт.

    Цена 1 510 ₽ вместо 1 525
  • Меларена таб. п/о плен., 3 мг, 30 шт.
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    Меларена таб. п/о плен., 3 мг, 30 шт.

    Цена 516 ₽ вместо 521
  • Флексотрон Соло импл. вязкоэластич. стер. для в/суст. ин., 22 мг/мл, 2 мл, 1 шт.
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1778175374_16/content/content/gallery":{"title":"Флексотрон Соло импл. вязкоэластич. стер. для в/суст. ин., 22 мг/мл, 2 мл, 1 шт.","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/4544006/img_id4573924690977915558.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/4544006/img_id4573924690977915558.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/4544006/img_id4573924690977915558.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/4544006/img_id4573924690977915558.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/4544006/img_id4573924690977915558.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/4544006/img_id4573924690977915558.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"},{"src":"https://avatars.mds.yandex.net/get-mpic/5251502/img_id7830085049915648000.jpeg/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/5251502/img_id7830085049915648000.jpeg/120x160 120w, https://avatars.mds.yandex.net/get-mpic/5251502/img_id7830085049915648000.jpeg/180x240 180w, https://avatars.mds.yandex.net/get-mpic/5251502/img_id7830085049915648000.jpeg/240x320 240w, https://avatars.mds.yandex.net/get-mpic/5251502/img_id7830085049915648000.jpeg/300x400 300w, https://avatars.mds.yandex.net/get-mpic/5251502/img_id7830085049915648000.jpeg/600x800 600w","sizes":"(max-width: 1456px) 15vw, 217px"}],"firstImageLazyLoading":false,"baobabClientData":{"realTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQuuuOyc6VivQ1EhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIWCI6b888GELq15cMDGMGn2Aog59zBBw==","sign":"/I/K7fTHzsn+fnfxHk6F+7rY1nUtkBKJ77IIVcM7KV8="},"target":"model_card"},"isNoPicturePadding":true}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1778175374_16/content/content/gallery":{"name":"@marketfront/SnippetConstructor/Gallery"}}}
    {"widgets":{"@marketfront/SnippetConstructor/ToggleWishlist":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1778175374_16/content/content/toggleWishlist":{"skuId":"947477178","productId":1778175374,"offerId":"QLOf5agZyFClTwbQmI-0bQ","size":24,"color":"#BDBDBC","wishlistLink":"/my/wishlist","baobabRealTimeEventPayload":{"version":"EPV_BRT_V1","payload":"CgoQuuuOyc6VivQ1EhoKGHJlbWl4X2Rlc2t0b3BfbW9kZWxfY2FyZDIWCI6b888GELq15cMDGMGn2Aog59zBBw==","sign":"/I/K7fTHzsn+fnfxHk6F+7rY1nUtkBKJ77IIVcM7KV8="},"waitWishlistCollections":false,"place":{"page":"product","widget":"feed"}}}},"meta":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1778175374_16/content/content/toggleWishlist":{"name":"@marketfront/SnippetConstructor/ToggleWishlist"}}}

    Флексотрон Соло импл. вязкоэластич. стер. для в/суст. ин., 22 мг/мл, 2 мл, 1 шт.

    Цена 15 939 ₽ вместо 16 100
  • Силденафил-СЗ таб. п/о плен., 25 мг, 20 шт.
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    Силденафил-СЗ таб. п/о плен., 25 мг, 20 шт.

    Цена 216 ₽
  • Эвалар чай Турбослим Очищение ф/п, 2 г, 20 шт.
    {"widgets":{"@marketfront/SnippetConstructor/Gallery":{"/content/page/fancyPage/recommendationRoll/content/lazyGenerator/initialContent/recomLayoutItem_21#1:1780250986_18/content/content/gallery":{"title":"Эвалар чай Турбослим Очищение ф/п, 2 г, 20 шт.","images":[{"src":"https://avatars.mds.yandex.net/get-mpic/2016828/img_id8119210648910150984.png/orig","srcSet":"https://avatars.mds.yandex.net/get-mpic/2016828/img_id8119210648910150984.png/120x160 120w, https://avatars.mds.yandex.net/get-mpic/2016828/img_id8119210648910150984.png/180x240 180w, https://avatars.mds.yandex.net/get-mpic/2016828/img_id8119210648910150984.png/240x320 240w, https://avatars.mds.yandex.net/get-mpic/2016828/img_id8119210648910150984.png/300x400 300w, https://avatars.mds.yandex.net/get-mpic/2016828/img_id8119210648910150984.png/600x800 600w","sizes":"(max-width: 1456px) 15vw, 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    Эвалар чай Турбослим Очищение ф/п, 2 г, 20 шт.

    Цена 351 ₽ вместо 418
  • Формула сна экспресс таб. д/рассас., 40 шт.
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    Формула сна экспресс таб. д/рассас., 40 шт.

    Цена 396 ₽ вместо 440
  • Персен Ночь капс., 10 шт.
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    Персен Ночь капс., 10 шт.

    Цена 294 ₽ вместо 297
  • Реклама
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  • Хронотрон имплантат инъекц. гель для в/суст. введ., 20 мг/мл, 2 мл, 1 шт.
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    Хронотрон имплантат инъекц. гель для в/суст. введ., 20 мг/мл, 2 мл, 1 шт.

    Цена 9 356 ₽ вместо 9 450
  • Донормил таб. п/о плен., 15 мг, 30 шт.
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    Донормил таб. п/о плен., 15 мг, 30 шт.

    Цена 516 ₽ вместо 619
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